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National Institute on Aging Virtual Workshop: Understanding Heterogeneity of Responses to, and Optimizing Clinical Efficacy of, Exercise Training in Older Adults
The Division of Geriatrics and Clinical Gerontology at the National Institute on Aging is pleased to sponsor the workshop “Understanding Heterogeneity of Responses to, and Optimizing Clinical Efficacy of, Exercise Training in Older Adults” on April 7-8, 2022.

The Division of Geriatrics and Clinical Gerontology at the National Institute on Aging (NIA) has launched an initiative focusing on the intersection of mechanistic and clinical perspectives of exercise responsiveness to disentangle the relationships between exercise training and physiologic responses. Exercise training interventions continue to be challenged by variations in the responsiveness, in particular in older adults. Given the pleiotropic effects of exercise, a wholistic approach to understanding exercise responsiveness is critically dependent on the outcome(s) on which responsiveness is based. For example, a positive response in one outcome may not always equal a positive response in another outcome. Other confounding factors include intrinsic (non-modifiable) and extrinsic (modifiable) influences. To accelerate research in this complex transdisciplinary area, the NIA is hosting a focused, virtual workshop to convene research leaders with expertise from different scientific fields.

The goals of this meeting are to:
• Provide brief, state-of-science updates on the variation in exercise response with regards to disease conditions/co-morbidities and targeted outcomes.
• Identify key research gaps and propose transdisciplinary research approaches to elucidate the relationships between endogenous/intrinsic and exogenous/extrinsic factors underlying the variations in exercise responses.
• Propose research opportunities to Identify systemic modulators biomarkers, and other potential mechanisms underlying exercise responsiveness.
• Advance work on this problem by stimulating cross-field scientific discussion, networking, and collaboration between investigators from different scientific fields.
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